Rapid formal hydrolysis of peptide-αthioesters.
نویسندگان
چکیده
In the presence of 2-mercaptoethanol peptide-(α)thioesters undergo smooth conversion to their corresponding peptide-(α)carboxylates. This general and operationally simple reaction extends the utility of a promising new strategy for cleaving resin-bound Boc/benzyl-protected peptides without the use of hydrogen fluoride.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 8 شماره
صفحات -
تاریخ انتشار 2013